2301. Neurodevelopment in Infants with Antenatal or Early Neonatal Exposure to SARS-CoV-2

Abstract Background Antenatal and neonatal viral exposure may put the developing brain at risk for abnormal neurodevelopment. A clinical follow-up program was created in Congenital Infection Program Children’s National Hospital to follow infants with utero or early life SARS-CoV-2. The aim of this study determine if SARS-CoV-2 have neurodevelopment infancy. Methods We performed a retrospective review all evaluated between 3/2020 – 11/2021. Demographic details, infection/testing data, pregnancy/birth specialty consult NICU records were extracted from infants’ medical charts. Infants divided into 3 groups: 1) antenatal symptomatic mother, 2) asymptomatic 3) infection. All received neurologic exam developmental screening Ages Stages Questionnaire (ASQ) 5 domains (Communication, Gross Motor, Fine Problem Solving, Personal-Social) during their evaluation. ASQ accounts prematurity. Outcomes interest an scores close below suggested cut-offs. Multivariate analysis used correlations group neurodevelopmental outcomes. Results Thirty-five seen up outpatient visits. Most (83%) exposed 16 mothers (Group 12 2); 1 chart did not symptom data. Six only as neonate 3). Group had exams mean (SD) age 112 (24) days (Table cut-offs (Fig. more frequently than Groups 2 3. likely score any cutoff compared (P=.04); domains, differences significant Motor (P=.01) Personal-Social (P=.02). Conclusion Early impact infant development, especially among those mother. Vaccination other precautions reduce spread symptoms protect against delays. Future work should prioritize longitudinal children exposure. Disclosures Authors: No reported disclosures.